Protein Details: Aquaporin-7
Protein ID
ICDB_Pro_0182
Protein Name
Aquaporin-7
Gene Name
AQP7; AQP7L; AQP9
Organism
Homo sapiens (Human)
Length
342 amino acids
AlphaFoldDB
AF-O14520-F1-model_v4.pdb
Function
Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH. The channel is also permeable to urea . Plays an important role in body energy homeostasis under conditions that promote lipid catabolism;giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream;glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity).
Sequence
Ligand Binding
Binding Site
SITE 135: "Important for permeability to glycerol"
Disease
Glycerol Quantitative Trait Locus and Body Mass Index Quantitative Trait Locus
Location
Detected in the sperm head (at protein level) (PubMed:28042826). Detected in white adipose tissue (PubMed:9405233).
DOI ID
10.1006/bbrc.1997.7769; 10.1046/j.1432-1033.2002.02821.x; 10.1038/ng1285; 10.1038/nature02465; 10.1101/gr.2596504; 10.3390/ijms18010066; 10.1016/j.metabol.2016.09.004; 10.3390/cells7110207; 10.1038/s41467-018-07176-z; 10.1210/jc.2007-0531
RefSeq
NP_001161.1 [O14520-1]; NP_001305086.1; NP_001305087.1; XP_005251510.1; XP_011516168.1